How Does Astrazeneca Vaccine Work?
Here, the gene that produces the spike protein of the corona virus has been inserted into an adenovirus. A modified chimpanzee adenovirus called ChAdOx1 was used in the vaccine for this purpose. (The Russian Sputnik vaccine contains a human adenovirus)
How can the AstraZeneca vaccine be stored at 2-8 degrees even though the Pfizer vaccine requires a storage temperature of 70 degrees?
DNA It is more stable than RNA and does not break down easily. Also, because it is inserted into an adenovirus, the adenovirus’s hard protein coat will bind to the inserted DNA. The part does not break. Therefore, there is no need to store at minus 70 degrees Celsius.
After the vaccine is given, the adeno virus binds to the proteins on the vaccinated cells. The virus enters the cell. Then reaches the nucleus. Adenovirus carries DNA into the nucleus. pushes According to genetic engineering, the adeno virus cannot produce its own copies, but the inserted corona virus spike part reads the gene part that produces the message RNA. (messenger RNA-mRNA) can be copied into a segment
M.R.N. The fragment leaves the nucleus. The cell’s molecules read its sequence and assemble the spike protein. Some of these produced spike proteins direct their spikes out of the cell. Some spike proteins break down and fragments are deposited on the cell surface. These stimulate the immune system in the body. Apart from that, adenovirus activates the body’s alarm system. It activates nearby immune cells. This is the method of making the immune system react strongly by Adenovirus by giving Astra Zeneca vaccine and this is a special point of the mechanism used by this vaccine to develop this immunity.
When/after the injected cell is destroyed, the spike proteins and protein fragments are captured by antigen-presenting cells. Spike proteins are located on the surface of antigen-presenting cells. These surface spike proteins are found by helper T cells. Helper T cells use other immune cells to produce immunity.
Other immune cells, B cells, attach to spike proteins on the injected cells or on free-floating ones. When these fixed B cells are activated by helper T cells, they multiply and produce antibodies.
If these antibodies enter the corona virus, they record the spike and lock the corona virus to destroy the virus. Also, the spike proteins of the corona virus are prevented from attaching to other body cells and prevent infection by the virus.